Requirement for active glycogen synthase kinase-3β in TGF-β(1) upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts

Connective tissue growth factor (CCN2/CTGF) mediates transforming growth factor-β (TGF-β)-induced fibrosis. Drug-induced gingival overgrowth is tissue specific. Here the role of the phosphoinositol 3-kinase (PI3K) pathway in mediating TGF-β(1)-stimulated CCN2/CTGF expression in primary human adult g...

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Hauptverfasser: Bahammam, Maha, Black, Samuel A., Sume, Siddika Selva, Assaggaf, Mohammad A., Faibish, Michael, Trackman, Philip C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761177/
https://ncbi.nlm.nih.gov/pubmed/23824844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00032.2013
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