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Requirement for active glycogen synthase kinase-3β in TGF-β(1) upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts
Connective tissue growth factor (CCN2/CTGF) mediates transforming growth factor-β (TGF-β)-induced fibrosis. Drug-induced gingival overgrowth is tissue specific. Here the role of the phosphoinositol 3-kinase (PI3K) pathway in mediating TGF-β(1)-stimulated CCN2/CTGF expression in primary human adult g...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3761177/ https://ncbi.nlm.nih.gov/pubmed/23824844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00032.2013 |
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