BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization

Pharmacological glucocorticoids (GCs) inhibit bone formation, leading to osteoporosis. GCs inhibit bone morphogenetic protein-2 (Bmp2) expression, and rhBMP-2 restores mineralization in GC-arrested osteoblast cultures. To better understand how GCs regulate BMPs, we investigated Bmp transcription, as...

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Bibliographic Details
Main Authors: LUPPEN, CYNTHIA A., CHANDLER, RONALD L., NOH, TOMMY, MORTLOCK, DOUGLAS P., FRENKEL, BARUCH
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760374/
https://ncbi.nlm.nih.gov/pubmed/19021035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08977190802277880
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