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CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tum...

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Detalhes bibliográficos
Main Authors: Ling, Hui, Spizzo, Riccardo, Atlasi, Yaser, Nicoloso, Milena, Shimizu, Masayoshi, Redis, Roxana S., Nishida, Naohiro, Gafà, Roberta, Song, Jian, Guo, Zhiyi, Ivan, Cristina, Barbarotto, Elisa, De Vries, Ingrid, Zhang, Xinna, Ferracin, Manuela, Churchman, Mike, van Galen, Janneke F., Beverloo, Berna H., Shariati, Maryam, Haderk, Franziska, Estecio, Marcos R., Garcia-Manero, Guillermo, Patijn, Gijs A., Gotley, David C., Bhardwaj, Vikas, Shureiqi, Imad, Sen, Subrata, Multani, Asha S., Welsh, James, Yamamoto, Ken, Taniguchi, Itsuki, Song, Min-Ae, Gallinger, Steven, Casey, Graham, Thibodeau, Stephen N., Le Marchand, Loïc, Tiirikainen, Maarit, Mani, Sendurai A., Zhang, Wei, Davuluri, Ramana V., Mimori, Koshi, Mori, Masaki, Sieuwerts, Anieta M., Martens, John W.M., Tomlinson, Ian, Negrini, Massimo, Berindan-Neagoe, Ioana, Foekens, John A., Hamilton, Stanley R., Lanza, Giovanni, Kopetz, Scott, Fodde, Riccardo, Calin, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759721/
https://ncbi.nlm.nih.gov/pubmed/23796952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.152942.112
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