SIRT6 dependent genetic and epigenetic alterations are associated with poor clinical outcome in HCC patients

Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD-dependent deacetylases. Genetic deletion of Sirt6 in mice results in a severe degenerative phenotype with impaired liver function and premature death. So far the role of SIRT6 in development and progression of hepatocellular carcinoma is unk...

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Main Authors: Marquardt, Jens U., Fischer, Kerstin, Baus, Katharina, Kashyap, Anubha, Ma, Shengyun, Krupp, Markus, Linke, Matthias, Teufel, Andreas, Zechner, Ulrich, Strand, Dennis, Thorgeirsson, Snorri S., Galle, Peter R., Strand, Susanne
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759627/
https://ncbi.nlm.nih.gov/pubmed/23526469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26413
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