Value of epithelioid morphology and PDGFRA immunostaining pattern for prediction of PDGFRA mutated genotype in gastrointestinal stromal tumors (GISTs)

Aims: Genotyping is a prerequisite for tyrosine kinase inhibitor therapy in high risk and malignant GIST. About 10% of GISTs are wild-type for KIT but carry PDGFRA mutations. Applying the traditional approach, mutation analysis of these cases is associated with higher costs if all hotspots regions i...

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Hlavní autoři: Agaimy, Abbas, Otto, Claudia, Braun, Alexander, Geddert, Helene, Schaefer, Inga-Marie, Haller, Florian
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759490/
https://ncbi.nlm.nih.gov/pubmed/24040448
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