Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy

Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. Glucagon-like peptide-1 (GLP-1) has β-cell protective effects and is known to preserve β-cells from STZ treatment. In this s...

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Main Authors: Tonne, Jason M., Sakuma, Toshie, Deeds, Michael C., Munoz-Gomez, Miguel, Barry, Michael A., Kudva, Yogish C., Ikeda, Yasuhiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Limited 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759343/
https://ncbi.nlm.nih.gov/pubmed/23828045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.012591
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