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SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

SOX2 (Sex-determining region Y (SRY)-Box2) has important functions during embryonic development and is involved in cancer stem cell (CSC) maintenance, in which it impairs cell growth and tumorigenicity. However, the function of SOX2 in pancreatic cancer cells is unclear. The objective of this study...

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Autors principals: Herreros-Villanueva, M, Zhang, J-S, Koenig, A, Abel, E V, Smyrk, T C, Bamlet, W R, de Narvajas, A A-M, Gomez, T S, Simeone, D M, Bujanda, L, Billadeau, D D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759123/
https://ncbi.nlm.nih.gov/pubmed/23917223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.23
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