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Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo
The NAD-synthesising enzyme Nmnat2 is a critical survival factor for axons in vitro and in vivo. We recently reported that loss of axonal transport vesicle association through mutations in its isoform-specific targeting and interaction domain (ISTID) reduces Nmnat2 ubiquitination, prolongs its half-...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3759051/ https://ncbi.nlm.nih.gov/pubmed/23995269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02567 |
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