Age-related Carbonylation of Fibro-cartilage Structural Proteins Drives Tissue Degenerative Modification

Aging-related oxidative stress has been linked to degenerative modifications in different organs and tissues. Using redox proteomic analysis and illustrative MS/MS mapping we demonstrate oxidative post-translational modifications in structural proteins of intervertebral discs (IVD) isolated from agi...

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Main Authors: Scharf, Brian, Clement, Cristina C., Yodmuang, Supansa, Urbanska, Aleksandra, Suadicani, Sylvia, Aphkhazava, David, Thi, Mia, Perino, Giorgio, Hardin, John A., Cobelli, Neil, Vunjak-Novakovic, Gordana, Santambrogio, Laura
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758909/
https://ncbi.nlm.nih.gov/pubmed/23890010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.06.006
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