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Tuning Ligand Density on Intravenous Hemostatic Nanoparticles Dramatically Increases Survival Following Blunt Trauma

Targeted nanoparticles are being pursued for a range of medical applications. Here, we utilized targeted nanoparticles (synthetic platelets) to halt bleeding in acute trauma. One of the major questions that arises in the field is the role of surface ligand density on targeted nanoparticles’ performa...

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Detalhes bibliográficos
Main Authors: Shoffstall, Andrew J., Everhart, Lydia M., Varley, Matthew E., Soehnlen, Eric S., Shick, Adam M., Ustin, Jeffrey S., Lavik, Erin B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758899/
https://ncbi.nlm.nih.gov/pubmed/23841817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm400619v
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