FANCD2-Deficient Human Fibroblasts Are Hypersensitive To Ionizing Radiation At Oxygen Concentrations Of 0% and 3% But Not Under Normoxic Conditions

PURPOSE: Individuals suffering from Fanconi Anemia (FA) exhibit a pronounced hypersensitivity to agents that cause DNA inter-strand crosslinks and frequently also to ionizing radiation. However, fibroblast lines derived from FA patients generally show little or no radiosensitivity in vitro. Here, we...

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Hlavní autoři: KUHNERT, VERENA M., KACHNIC, LISA A., LI, LI, PURSCHKE, MARTIN, GHEORGHIU, LILIANA, LEE, RICHARD, HELD, KATHRYN D., WILLERS, HENNING
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758881/
https://ncbi.nlm.nih.gov/pubmed/19466639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09553000902883810
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