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Chondroitinase ABC Combined with Neurotrophin NT-3 Secretion and NR2D Expression Promotes Axonal Plasticity and Functional Recovery in Rats with Lateral Hemisection of the Spinal Cord

Elevating spinal levels of neurotrophin NT-3 (NT3) while increasing expression of the NR2D subunit of the NMDA receptor using a HSV viral construct promotes formation of novel multisynaptic projections from lateral white matter (LWM) axons to motoneurons in neonates. However, this treatment is ineff...

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Autors principals: García-Alías, Guillermo, Petrosyan, Hayk A., Schnell, Lisa, Horner, Philip J., Bowers, William J., Mendell, Lorne M., Fawcett, James W., Arvanian, Victor L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758578/
https://ncbi.nlm.nih.gov/pubmed/22159095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4308-11.2011
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