Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

Leptin regulates body weight in mice by decreasing appetite and increasing sympathetic nerve activity (SNA), which increases energy expenditure in interscapular brown adipose tissue (iBAT). Diet-induced obese mice (DIO) are resistant to the anorectic actions of leptin. We evaluated whether leptin st...

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Main Authors: Enriori, Pablo J., Sinnayah, Puspha, Simonds, Stephanie E., Garcia Rudaz, Cecilia, Cowley, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758545/
https://ncbi.nlm.nih.gov/pubmed/21865462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2336-11.2011
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