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Ubiquitin E3 ligase Itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells
Itch, a HECT family E3 ligase, affects numerous cell functions by regulating ubiquitination and proteasomal degradation of target proteins. However, the role of Itch in osteoblasts has not been investigated. We report that Itch(−/−) mice have significantly increased bone volume, osteoblast numbers a...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758407/ https://ncbi.nlm.nih.gov/pubmed/23606569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1395 |
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