The HTR3A polymorphism c. -42C>T is Associated with Amygdala Responsiveness in Patients with Irritable Bowel Syndrome

BACKGROUND & AIMS: 5-HT3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphi...

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Autores principales: Kilpatrick, LA, Labus, JS, Coveleskie, K, Hammer, C, Rappold, G, Tillisch, K, Bueller, JA, Suyenobu, B, Jarcho, JM, McRoberts, JA, Niesler, B, Mayer, EA
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757951/
https://ncbi.nlm.nih.gov/pubmed/21420406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.03.011
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