Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications

Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis. Protein tyrosine phosphatase delta (PTPRD) is a tumor suppressor that inhibits STAT3 activation. To date, w...

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Autori principali: Jiang, Yunyun, Janku, Filip, Subbiah, Vivek, Angelo, Laura S., Naing, Aung, Anderson, Peter M., Herzog, Cynthia E., Fu, Siqing, Benjamin, Robert S., Kurzrock, Razelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2013
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757245/
https://ncbi.nlm.nih.gov/pubmed/23800680
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