PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

PHD1 belongs to the family of prolyl-4-hydroxylases (PHDs) that is responsible for posttranslational modification of prolines on specific target proteins. Because PHD activity is sensitive to oxygen levels and certain byproducts of the tricarboxylic acid cycle, PHDs act as sensors of the cell’s meta...

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Main Authors: Moser, Sandra C., Bensaddek, Dalila, Ortmann, Brian, Maure, Jean-Francois, Mudie, Sharon, Blow, J. Julian, Lamond, Angus I., Swedlow, Jason R., Rocha, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757158/
https://ncbi.nlm.nih.gov/pubmed/23932902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.06.014
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