Reduced gravitational loading does not account for the skeletal effect of botulinum toxin-induced muscle inhibition suggesting a direct effect of muscle on bone

Intramuscular injection of botulinum toxin (botox) into rodent hindlimbs has developed as a useful model for exploring muscle–bone interactions. Botox-induced muscle inhibition rapidly induces muscle atrophy and subsequent bone loss, with the latter hypothesized to result from reduced muscular loadi...

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Detalhes bibliográficos
Main Authors: Warden, Stuart J., Galley, Matthew R., Richard, Jeffrey S., George, Lydia A., Dirks, Rachel C., Guildenbecher, Elizabeth A., Judd, Ashley M., Robling, Alexander G., Fuchs, Robyn K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757093/
https://ncbi.nlm.nih.gov/pubmed/23388417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2013.01.043
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