Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

A non-toxic, nine residue peptide, NIVNVSLVK is shown to interfere with insulin fibrillation by various biophysical methods. Insulin undergoes conformational changes under certain stress conditions leading to amyloid fibrils. Fibrillation of insulin poses a problem in its long-term storage, reducing...

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Bibliographische Detailangaben
Hauptverfasser: Banerjee, Victor, Kar, Rajiv K., Datta, Aritreyee, Parthasarathi, Krupakar, Chatterjee, Subhrangsu, Das, Kali P., Bhunia, Anirban
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756998/
https://ncbi.nlm.nih.gov/pubmed/24009675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072318
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