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Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability

How subunit dosage contributes to the assembly and function of multimeric complexes is an important question with implications in understanding biochemical, evolutionary, and disease mechanisms. Toward identifying pathways that are susceptible to decreased gene dosage, we performed a genome-wide scr...

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Detalhes bibliográficos
Main Authors: Choy, John S., O'Toole, Eileen, Schuster, Breanna M., Crisp, Matthew J., Karpova, Tatiana S., McNally, James G., Winey, Mark, Gardner, Melissa K., Basrai, Munira A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756926/
https://ncbi.nlm.nih.gov/pubmed/23825022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-12-0902
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