Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

Expression of long-lasting synaptic plasticity and long-term memory requires new protein synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2α subunit (eIF2α). It was reported previously that eIF2α phosphorylation is elevated in the brains of Alzheimer’s disease (AD...

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Main Authors: Ma, Tao, Trinh, Mimi A., Wexler, Alyse J., Bourbon, Clarisse, Gatti, Evelina, Pierre, Philippe, Cavener, Douglas R., Klann, Eric
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756900/
https://ncbi.nlm.nih.gov/pubmed/23933749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3486
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