Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9

Eukaryotic genomes harbor transposable elements and other repetitive sequences that must be silenced. Small RNA interference pathways play a major role in their repression. Here, we reveal another mechanism for silencing these sequences in Drosophila. Depleting the linker histone H1 in vivo leads to...

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Autores principales: Lu, Xingwu, Wontakal, Sandeep N., Kavi, Harsh, Kim, Byung Ju, Guzzardo, Paloma M., Emelyanov, Alexander V., Xu, Na, Hannon, Gregory J., Zavadil, Jiri, Fyodorov, Dmitry V., Skoultchi, Arthur I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756538/
https://ncbi.nlm.nih.gov/pubmed/23559249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234654
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