Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384

ABT-384 is a potent, selective inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 (HSD-1). One milligram of ABT-384 daily fully inhibited hepatic HSD-1. Establishing the dose that fully inhibits central nervous system (CNS) HSD-1 would enable definitive clinical studies in potential CNS indica...

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Detalhes bibliográficos
Main Authors: Katz, D A, Liu, W, Locke, C, Jacobson, P, Barnes, D M, Basu, R, An, G, Rieser, M J, Daszkowski, D, Groves, F, Heneghan, G, Shah, A, Gevorkyan, H, Jhee, S S, Ereshefsky, L, Marek, G J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756293/
https://ncbi.nlm.nih.gov/pubmed/23982627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2013.67
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