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DNA crosslinking damage and cancer - a tale of friend and foe
Interstrand crosslinks (ICLs) represent a major challenge for DNA replication and transcription by preventing DNA strand separation. Cells deficient in ICL repair are hypersensitive to a variety of bifunctional alkylating agents and exhibit excessive genomic instability. Patients with deficient ICL...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755464/ https://ncbi.nlm.nih.gov/pubmed/23998004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2218-676X.2013.03.01 |
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