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Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity
Renal cell carcinomas (RCCs) are frequently occurring genitourinary malignancies in the aged population. A morphological characteristic of RCCs is an irregular nuclear shape, which is used to index cancer grades. Other features of RCCs include the genetic inactivation of the von Hippel-Lindau gene,...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Landes Bioscience
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3755078/ https://ncbi.nlm.nih.gov/pubmed/24067370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25371 |
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