Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity

Renal cell carcinomas (RCCs) are frequently occurring genitourinary malignancies in the aged population. A morphological characteristic of RCCs is an irregular nuclear shape, which is used to index cancer grades. Other features of RCCs include the genetic inactivation of the von Hippel-Lindau gene,...

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Main Authors: Jung, Youn-Sang, Lee, Su-Jin, Lee, Sun-Hye, Chung, Ji-Yun, Jung, Youn Jin, Hwang, Sang Hyun, Ha, Nam-Chul, Park, Bum-Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755078/
https://ncbi.nlm.nih.gov/pubmed/24067370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25371
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