The HIV-1 Protein Vpr Targets the Endoribonuclease Dicer for Proteasomal Degradation to Boost Macrophage Infection

The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4(DCAF1) ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands. Corresponding ubiquitination targets have not been identified....

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Main Authors: Klockow, Laurieann Casey, Sharifi, Hamayun J., Wen, Xiaoyun, Flagg, Meg, Furuya, Andrea K. M., Nekorchuk, Michael, de Noronha, Carlos M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755019/
https://ncbi.nlm.nih.gov/pubmed/23849790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.06.010
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