DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

Heavy-ion irradiation induces a higher frequency of DNA double strand breaks (DSBs) which must be properly repaired. Critical shortening of telomeres can trigger DNA damage responses such as DSBs. Telomeres are very sensitive to oxidative stress such as ionizing radiation. The DNA-dependent protein...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhou, Xin, Zhang, Xin, Xie, Yi, Tanaka, Kaoru, Wang, Bing, Zhang, Hong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754927/
https://ncbi.nlm.nih.gov/pubmed/24013362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072641
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