Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity

Salicylidene acylhydrazides (SAHs) inhibit the type III secretion system (T3S) of Yersinia and other Gram-negative bacteria. In addition, SAHs restrict the growth and development of Chlamydia species. However, since the inhibition of Chlamydia growth by SAH is suppressed by the addition of excess ir...

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Main Authors: Engström, Patrik, Nguyen, Bidong D., Normark, Johan, Nilsson, Ingela, Bastidas, Robert J., Gylfe, Åsa, Elofsson, Mikael, Fields, Kenneth A., Valdivia, Raphael H., Wolf-Watz, Hans, Bergström, Sven
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754756/
https://ncbi.nlm.nih.gov/pubmed/23852872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00506-13
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