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Targeting lactate metabolism for cancer therapeutics

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate with increased metastasis, tumor recurrence, and poor outcome. Lactate mediates cancer cell intrinsic effects on meta...

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Bibliografiske detaljer
Main Authors: Doherty, Joanne R., Cleveland, John L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754272/
https://ncbi.nlm.nih.gov/pubmed/23999443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69741
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