Poison Domains Block Transit of Translocated Substrates via the Legionella pneumophila Icm/Dot System

Legionella pneumophila uses the Icm/Dot type 4B secretion system (T4BSS) to deliver translocated protein substrates to the host cell, promoting replication vacuole formation. The conformational state of the translocated substrates within the bacterial cell is unknown, so we sought to determine if fo...

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Bibliographic Details
Main Authors: Amyot, Whitney M., deJesus, Dennise, Isberg, Ralph R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754216/
https://ncbi.nlm.nih.gov/pubmed/23798536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00552-13
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