LacR Mutations Are Frequently Observed in Streptococcus intermedius and Are Responsible for Increased Intermedilysin Production and Virulence

Streptococcus intermedius secretes a human-specific cytolysin, intermedilysin (ILY), which is considered to be the major virulence factor of this pathogen. We screened for a repressor of ily expression by using random gene disruption in a low-ILY-producing strain (PC574). Three independent high-ILY-...

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Autores principales: Tomoyasu, Toshifumi, Imaki, Hidenori, Masuda, Sachiko, Okamoto, Ayumi, Kim, Hyejin, Waite, Richard D., Whiley, Robert A., Kikuchi, Ken, Hiramatsu, Keiichi, Tabata, Atsushi, Nagamune, Hideaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Molecular Pathogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754192/
https://ncbi.nlm.nih.gov/pubmed/23798532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00638-13
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