Coagulation Factor Binding Orientation and Dimerization May Influence Infectivity of Adenovirus-Coagulation Factor Complexes

Adenoviruses (Ads) are promising vectors for therapeutic interventions in humans. When injected into the bloodstream, Ad vectors can bind several vitamin K-dependent blood coagulation factors, which contributes to virus sequestration in the liver by facilitating transduction of hepatocytes. Although...

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Bibliographic Details
Main Authors: Irons, Eric E., Flatt, Justin W., Doronin, Konstantin, Fox, Tara L., Acchione, Mauro, Stewart, Phoebe L., Shayakhmetov, Dmitry M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754089/
https://ncbi.nlm.nih.gov/pubmed/23804638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01070-13
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