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Echovirus 1 Entry into Polarized Caco-2 Cells Depends on Dynamin, Cholesterol, and Cellular Factors Associated with Macropinocytosis

Enteroviruses invade their hosts by crossing the intestinal epithelium. We have examined the mechanism by which echovirus 1 (EV1) enters polarized intestinal epithelial cells (Caco-2). Virus binds to VLA-2 on the apical cell surface and moves rapidly to early endosomes. Using inhibitory drugs, domin...

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Bibliografski detalji
Glavni autori: Krieger, Sophie E., Kim, Chonsaeng, Zhang, Lili, Marjomaki, Varpu, Bergelson, Jeffrey M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754084/
https://ncbi.nlm.nih.gov/pubmed/23740983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03415-12
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