The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression

Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of human diseases, including neurodegenerative disorders. Thus, stimulating proteasome activity is a promising strategy to ameliorate these age-related diseases. Here we show that the protein kinase casein ki...

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Hauptverfasser: Tsuchiya, Yoshiki, Taniguchi, Hiroaki, Ito, Yoshiyuki, Morita, Tomoko, Karim, M. Rezaul, Ohtake, Norihito, Fukagai, Kousuke, Ito, Takao, Okamuro, Shota, Iemura, Shun-ichiro, Natsume, Tohru, Nishida, Eisuke, Kobayashi, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753846/
https://ncbi.nlm.nih.gov/pubmed/23816881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01271-12
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