Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides

Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires a rapid, sensitive, flexible and unbiased technique able to visualize the in vivo biodistribution o...

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Autori principali: Boos, Julien A., Kirk, David W., Piccolotto, Mari-Luz, Zuercher, Werner, Gfeller, Sandro, Neuner, Philippe, Dattler, Andre, Wishart, William L., Von Arx, Fabian, Beverly, Michael, Christensen, Jesper, Litherland, Karine, van de Kerkhof, Esther, Swart, Pieter J., Faller, Thomas, Beyerbach, Armin, Morrissey, David, Hunziker, Juerg, Beuvink, Iwan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753639/
https://ncbi.nlm.nih.gov/pubmed/23766292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt515
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