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Development of Novel Rifampicin-Derived P-Glycoprotein Activators/Inducers. Synthesis, In Silico Analysis and Application in the RBE4 Cell Model, Using Paraquat as Substrate

P-glycoprotein (P-gp) is a 170 kDa transmembrane protein involved in the outward transport of many structurally unrelated substrates. P-gp activation/induction may function as an antidotal pathway to prevent the cytotoxicity of these substrates. In the present study we aimed at testing rifampicin (R...

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Detalhes bibliográficos
Main Authors: Vilas-Boas, Vânia, Silva, Renata, Palmeira, Andreia, Sousa, Emília, Ferreira, Luísa Maria, Branco, Paula Sério, Carvalho, Félix, Bastos, Maria de Lourdes, Remião, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753303/
https://ncbi.nlm.nih.gov/pubmed/23991219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074425
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