An In vivo Drug Screening Model Using Glucose-6-Phosphate Dehydrogenase Deficient Mice to Predict the Hemolytic Toxicity of 8-Aminoquinolines

Anti-malarial 8-aminoquinolines drugs cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDD). Efforts to develop non-hemolytic 8-aminoquinolines have been severely limited caused by the lack of a predictive in vivo animal model of hemolytic potential th...

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Autori principali: Zhang, Peng, Gao, Xiugong, Ishida, Hiroshi, Amnuaysirikul, Jack, Weina, Peter J., Grogl, Max, O'Neil, Michael T., Li, Qigui, Caridha, Diana, Ohrt, Colin, Hickman, Mark, Magill, Alan J., Ray, Prabhati
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Tropical Medicine and Hygiene 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752814/
https://ncbi.nlm.nih.gov/pubmed/23530079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.12-0682
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