A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

OBJECTIVE: Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that...

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Detalhes bibliográficos
Main Authors: Huan, Tianxiao, Zhang, Bin, Wang, Zhi, Joehanes, Roby, Zhu, Jun, Johnson, Andrew D., Ying, Saixia, Munson, Peter J., Raghavachari, Nalini, Wang, Richard, Liu, Poching, Courchesne, Paul, Hwang, Shih-Jen, Assimes, Themistocles L., McPherson, Ruth, Samani, Nilesh J., Schunkert, Heribert, Meng, Qingying, Suver, Christine, O'Donnell, Christopher J., Derry, Jonathan, Yang, Xia, Levy, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752786/
https://ncbi.nlm.nih.gov/pubmed/23539213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300112
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