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A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases
Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control specific genes. Acyl-HSL synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid donor. We developed and executed an enzyme-coupled high-throughput cell-free screen to d...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752275/ https://ncbi.nlm.nih.gov/pubmed/23924613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313098110 |
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