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A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases

Many Proteobacteria use N-acyl-homoserine lactone (acyl-HSL) quorum sensing to control specific genes. Acyl-HSL synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid donor. We developed and executed an enzyme-coupled high-throughput cell-free screen to d...

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Bibliografiske detaljer
Main Authors: Christensen, Quin H., Grove, Tyler L., Booker, Squire J., Greenberg, E. Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752275/
https://ncbi.nlm.nih.gov/pubmed/23924613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313098110
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