Loss of Retinoschisin (RS1) Cell Surface Protein in Maturing Mouse Rod Photoreceptors Elevates the Luminance Threshold for Light-Driven Translocation of Transducin But Not Arrestin

Loss of retinoschisin (RS1) in Rs1 knock-out (Rs1–KO) retina produces a post-photoreceptor phenotype similar to X-linked retinoschisis in young males. However, Rs1 is expressed strongly in photoreceptors, and Rs1–KO mice have early reduction in the electroretinogram a-wave. We examined light-activat...

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Main Authors: Ziccardi, Lucia, Vijayasarathy, Camasamudram, Bush, Ronald A., Sieving, Paul A.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2012
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752084/
https://ncbi.nlm.nih.gov/pubmed/22993419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1913-12.2012
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