Interferon and Ribavirin Combination Treatment Synergistically Inhibit HCV Internal Ribosome Entry Site Mediated Translation at the Level of Polyribosome Formation

PURPOSE: Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV...

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Detalhes bibliográficos
Main Authors: Panigrahi, Rajesh, Hazari, Sidhartha, Chandra, Sruti, Chandra, Partha K., Datta, Sibnarayan, Kurt, Ramazan, Cameron, Craig E., Huang, Zhuhui, Zhang, Haitao, Garry, Robert F., Balart, Luis A., Dash, Srikanta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751885/
https://ncbi.nlm.nih.gov/pubmed/24009705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072791
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