Detergent-Resistant Membrane Microdomains Facilitate Ib Oligomer Formation and Biological Activity of Clostridium perfringens Iota-Toxin

Clostridium perfringens iota-toxin consists of two separate proteins identified as a cell binding protein, iota b (Ib), which forms high-molecular-weight complexes on cells generating Na(+)/K(+)-permeable pores through which iota a (Ia), an ADP-ribosyltransferase, presumably enters the cytosol. Iden...

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Autors principals: Hale, Martha L., Marvaud, Jean-Christophe, Popoff, Michel R., Stiles, Bradley G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC375178/
https://ncbi.nlm.nih.gov/pubmed/15039342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.4.2186-2193.2004
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