Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9

BACKGROUND: Studies in animals showed that PCSK9 is involved in HDL metabolism. We investigated the molecular mechanism by which PCSK9 regulates HDL cholesterol concentration and also whether Pcsk9 inactivation might affect cholesterol efflux capacity of serum and atherosclerotic fatty streak volume...

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Main Authors: Choi, Seungbum, Aljakna, Aleksandra, Srivastava, Ujala, Peterson, Blake R, Deng, Bin, Prat, Annik, Korstanje, Ron
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751695/
https://ncbi.nlm.nih.gov/pubmed/23883163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-12-112
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