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Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment

BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells. Treatment with the novel HIF-1 stabilizing drug AKB-4924 has been shown to enhance the bactericidal activity of keratinocytes as well as...

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Autors principals: Leire, Emma, Olson, Josh, Isaacs, Hart, Nizet, Victor, Hollands, Andrew
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751314/
https://ncbi.nlm.nih.gov/pubmed/23937964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-10-28
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