Epigenetic silencing of RASSF1A deregulates cytoskeleton and promotes malignant behavior of adrenocortical carcinoma

BACKGROUND: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is...

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Detalhes bibliográficos
Main Authors: Korah, Reju, Healy, James M, Kunstman, John W, Fonseca, Annabelle L, Ameri, Amir H, Prasad, Manju L, Carling, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750604/
https://ncbi.nlm.nih.gov/pubmed/23915220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-87
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