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How αβ T cells deal with induced TCRα ablation

On deletion of the gene encoding the constant region of the T cell antigen receptor (TCR)α chain in mature T cells by induced Cre-mediated recombination, the cells lose most of their TCR from the cell surface within 7–10 days, but minute amounts of surface-bound TCRβ chains are retained for long per...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Polic, Bojan, Kunkel, Desiree, Scheffold, Alexander, Rajewsky, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447257/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141218898
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