FGFR3 has tumor suppressor properties in cells with epithelial phenotype

BACKGROUND: Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears paradoxical. RESULTS: FGFR3 expression was forced in pancreatic cell lines. The...

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Bibliografiske detaljer
Main Authors: Lafitte, Marie, Moranvillier, Isabelle, Garcia, Stéphane, Peuchant, Evelyne, Iovanna, Juan, Rousseau, Benoit, Dubus, Pierre, Guyonnet-Dupérat, Véronique, Belleannée, Geneviève, Ramos, Jeanne, Bedel, Aurélie, de Verneuil, Hubert, Moreau-Gaudry, François, Dabernat, Sandrine
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750311/
https://ncbi.nlm.nih.gov/pubmed/23902722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-83
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