FGFR3 has tumor suppressor properties in cells with epithelial phenotype

BACKGROUND: Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears paradoxical. RESULTS: FGFR3 expression was forced in pancreatic cell lines. The...

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Detalhes bibliográficos
Main Authors: Lafitte, Marie, Moranvillier, Isabelle, Garcia, Stéphane, Peuchant, Evelyne, Iovanna, Juan, Rousseau, Benoit, Dubus, Pierre, Guyonnet-Dupérat, Véronique, Belleannée, Geneviève, Ramos, Jeanne, Bedel, Aurélie, de Verneuil, Hubert, Moreau-Gaudry, François, Dabernat, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750311/
https://ncbi.nlm.nih.gov/pubmed/23902722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-83
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