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REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

BACKGROUND: Genetic alterations of transcription factors (TFs) have been implicated in the tumorigenesis of cancers. In many cancers, alteration of TFs results in aberrant activity of them without changing their gene expression level. Gene expression data from microarray or RNA-seq experiments can c...

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Hlavní autoři: Zhu, Mingzhu, Liu, Chun-Chi, Cheng, Chao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750236/
https://ncbi.nlm.nih.gov/pubmed/23885756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-504
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